Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes.

BMC genomics - 11 Apr 2012

Palgi Mari, Greco Dario, Lindström Riitta, Auvinen Petri, Heino Tapio I

Abstract excerpt

BACKGROUND: MANF and CDNF are evolutionarily conserved neurotrophic factors that specifically support dopaminergic neurons. To date, the receptors and signalling pathways of this novel MANF/CDNF family have remained unknown. Independent studies have showed upregulation of MANF by unfolded protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carbohydrate Metabolism
Share to Dopamine
Share to Exocytosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrolases

Share to Inheritance Patterns

Share to Lysosomes

Share to Nerve Growth Factors

Share to Unfolded Protein Response

Source

Open in PubMed Open full text

Identifiers

PMID: 22494833
DOI: 10.1186/1471-2164-13-134
PMCID: PMC3364883

Genes

MANF
CDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22494833-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes.PMID 22494833Read ↗

Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster.Semantic proximity Read ↗

The neurotrophic factor MANF regulates autophagy and lysosome function to promote proteostasis in Caenorhabditis elegansSemantic proximity Read ↗

C. elegans MANF Homolog Is Necessary for the Protection of Dopaminergic Neurons and ER Unfolded Protein ResponseSemantic proximity Read ↗

Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons.Semantic proximity Read ↗

The spliceosome-associated protein Mfap1 binds to VCP in Drosophila.Semantic proximity Read ↗

Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factorSemantic proximity Read ↗

Mitofusin-Dependent ER Stress Triggers Glial Dysfunction and Nervous System Degeneration in a Drosophila Model of Friedreich’s AtaxiaSemantic proximity Read ↗

MANF silencing, immunity induction or autophagy trigger an unusual cell type in metamorphosing Drosophila brainSemantic proximity Read ↗

Kinetic Monitoring Of Neuronal Stress Response To Proteostasis DysfunctionSemantic proximity Read ↗

Glia-derived secretory fatty acid binding protein Obp44a regulates lipid storage and efflux in the developing <i>Drosophila</i> brainSemantic proximity Read ↗

Protein expression profiling of the drosophila fragile X mutant brain reveals up-regulation of monoamine synthesis.Semantic proximity Read ↗

Drosophila fragile X protein, DFXR, regulates neuronal morphology and function in the brain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.