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Article

Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons.

Proceedings of the National Academy of Sciences of the United States of America - 17 Feb 2009

Palgi Mari, Lindström Riitta, Peränen Johan, Piepponen T Petteri, Saarma Mart, Heino Tapio I

Abstract excerpt

In vertebrates the development and function of the nervous system is regulated by neurotrophic factors (NTFs). Despite extensive searches no neurotrophic factors have been found in invertebrates. However, cell ablation studies in Drosophila suggest trophic interaction between neurons and glia. Here we report the invertebrate neurotrophic factor in Drosophila, DmMANF, homologous to mammalian MANF and CDNF. DmMANF...

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Source

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Identifiers

PMID: 19164766
DOI: 10.1073/pnas.0810996106
PMCID: PMC2650173

Genes

MANF
CDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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