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Article

Identification of 67 Pleiotropic Genes Associated With Seven Autoimmune/Autoinflammatory Diseases Using Multivariate Statistical Analysis.

Frontiers in immunology - 1 Jan 2020

Jia Xiaocan, Shi Nian, Feng Yu, Li Yifan, Tan Jiebing, Xu Fei, Wang Wei, Sun Changqing, Deng Hongwen, Yang Yongli, Shi Xuezhong

Abstract excerpt

Although genome-wide association studies (GWAS) have a dramatic impact on susceptibility locus discovery, this univariate approach has limitations in detecting complex genotype-phenotype correlations. Multivariate analysis is essential to identify shared genetic risk factors acting through common biological mechanisms of autoimmune/autoinflammatory diseases. In this study, GWAS summary statistics, including...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32117227
DOI: 10.3389/fimmu.2020.00030
PMCID: PMC7008725

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