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Molecular Basis of Familial and Sporadic Alzheimer's Disease

20 Jul 2016

Abstract excerpt

Alzheimer's disease (AD) is a multifactorial disease with genetic (70%) and environmental (30%) causes. Among the genetic factors are genes associated with a family history of the disease (familial AD, FAD) and sporadic AD (SAD). The genes: APP (amyloid precursor protein), PSEN1 (Presenilin 1) and PSEN2 (Presenilin 2) are responsible for the presence of FAD. The APOE gene is responsible for the sporadic form of...

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PMID: 26971934
DOI: 10.2174/1567205013666160314150501

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