Molecular pathogenesis of sporadic and familial forms of Alzheimer's disease.

doi:10.1016/s1357-4310(98)01229-5

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Article

Molecular pathogenesis of sporadic and familial forms of Alzheimer's disease.

Molecular medicine today - 1 Apr 1998

Ray W J, Ashall F, Goate A M

Abstract excerpt

Our understanding of the pathogenesis of Alzheimer's disease (AD) comes primarily from the study of rare inherited forms of the disease. Mutations that cause familial AD appear to act by a common mechanism: that of increasing production of A beta 42/43, one of the family of A beta peptides deposi...

Topics

Age of Onset
Aged
Alleles
Alzheimer Disease
Amyloid beta-Protein Precursor
Apolipoprotein E4
Apolipoproteins E
Biomarkers
Brain
Brain Chemistry
Butyrylcholinesterase
Calcium
Cardiovascular Diseases
Disease Susceptibility
Genes, Dominant
Humans
Inflammation
Membrane Proteins

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