Article
Molecular pathogenesis of sporadic and familial forms of Alzheimer's disease.
Molecular medicine today - 1 Apr 1998
Ray W J, Ashall F, Goate A M
Abstract excerpt
Our understanding of the pathogenesis of Alzheimer's disease (AD) comes primarily from the study of rare inherited forms of the disease. Mutations that cause familial AD appear to act by a common mechanism: that of increasing production of A beta 42/43, one of the family of A beta peptides deposited in senile plaques. However, increased A beta 42/43 production has not been demonstrated to occur in most cases of...
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