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Article

High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast.

PLoS genetics - 1 Mar 2016

Andersen Sabrina L, Zhang Aimee, Dominska Margaret, Moriel-Carretero María, Herrera-Moyano Emilia, Aguilera Andrés, Petes Thomas D

Abstract excerpt

The Saccharomyces cerevisae RAD3 gene is the homolog of human XPD, an essential gene encoding a DNA helicase of the TFIIH complex involved in both nucleotide excision repair (NER) and transcription. Some mutant alleles of RAD3 (rad3-101 and rad3-102) have partial defects in DNA repair and a strong hyper-recombination (hyper-Rec) phenotype. Previous studies showed that the hyper-Rec phenotype associated with...

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Identifiers

PMID: 26968037
DOI: 10.1371/journal.pgen.1005938
PMCID: PMC4788294

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