Article
Effects of multiple yeast rad3 mutant alleles on UV sensitivity, mutability, and mitotic recombination.
Journal of bacteriology - 1 Dec 1990
Song J M, Montelone B A, Siede W, Friedberg E C
Abstract excerpt
A yeast strain was constructed that had a disruption of the chromosomal RAD3 gene and carried a series of centromeric plasmids with defined mutations in this gene. Using this isogenic collection, we examined sensitivity to UV radiation, spontaneous and UV radiation-induced mutagenesis, and mitotic recombination. Several alleles resulted in a marked increase in UV sensitivity. Most of these alleles were found to...
Topics
- Alleles
- Amino Acid Sequence
- DNA Damage
- DNA Helicases
- DNA Repair
- DNA, Fungal
- Genes, Fungal
- Mitosis
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Plasmids