Article
Longitudinal Frequencies of Blood Leukocyte Subpopulations Differ between NOD and NOR Mice but Do Not Predict Diabetes in NOD Mice.
Journal of diabetes research - 1 Jan 2016
Telieps Tanja, Köhler Meike, Treise Irina, Foertsch Katharina, Adler Thure, Busch Dirk H, Hrabě de Angelis Martin, Verschoor Admar, Adler Kerstin, Bonifacio Ezio, Ziegler Anette-Gabriele
Abstract excerpt
Immune phenotyping provides insight into disease pathogenesis and prognostic markers. Trajectories from age of 4 to 36 weeks were modeled for insulin autoantibodies and for leukocyte subpopulations in peripheral blood from female NOD (n = 58) and NOR (n = 22) mice. NOD mice had higher trajectories of insulin autoantibodies, CD4(+) and CD8(+) T lymphocytes, B lymphocytes, IgD(+)IgM(-) B lymphocytes, and NK cells...
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