Article
Paradoxical leanness in the imprinting-centre deletion mouse model for Prader-Willi syndrome.
The Journal of endocrinology - 1 Jan 2017
Golding David M, Rees Daniel J, Davies Jennifer R, Relkovic Dinko, Furby Hannah V, Guschina Irina A, Hopkins Anna L, Davies Jeffrey S, Resnick James L, Isles Anthony R, Wells Timothy
Abstract excerpt
Prader-Willi syndrome (PWS), a neurodevelopmental disorder caused by loss of paternal gene expression from 15q11-q13, is characterised by growth retardation, hyperphagia and obesity. However, as single gene mutation mouse models for this condition display an incomplete spectrum of the PWS phenotype, we have characterised the metabolic impairment in a mouse model for 'full' PWS, in which deletion of the imprinting...
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