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Article

Fetal overgrowth in the Cdkn1c mouse model of Beckwith-Wiedemann syndrome.

Disease models & mechanisms - 1 Nov 2011

Tunster Simon J, Van de Pette Mathew, John Rosalind M

Abstract excerpt

Mutations in the imprinted CDKN1C gene are associated with the childhood developmental disorder Beckwith-Wiedemann syndrome (BWS). Multiple mouse models with deficiency of Cdkn1c recapitulate some aspects of BWS but do not exhibit overgrowth of the newborn, a cardinal feature of patients with BWS. In this study, we found that Cdkn1c mutants attained a 20% increase in weight during gestation but experienced a...

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Identifiers

PMID: 21729874
DOI: 10.1242/dmm.007328
PMCID: PMC3209650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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