Article
Epidermal growth factor receptor regulates pancreatic fibrosis.
American journal of physiology. Gastrointestinal and liver physiology - 1 Sept 2009
Blaine Stacy A, Ray Kevin C, Branch Kevin M, Robinson Pamela S, Whitehead Robert H, Means Anna L
Abstract excerpt
The development of pancreatic fibrosis has been shown to be a major component in several diseases of the pancreas including pancreatic cancer, chronic pancreatitis, and type 2 diabetes mellitus, but its actual role in the progression of these disorders is still unknown. This fibrosis is characterized by stromal expansion and the excessive deposition of extracellular matrix (ECM) that replaces pancreatic tissue....
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