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Article

Absence of Prenatal Forebrain Defects in the Dp(16)1Yey/+ Mouse Model of Down Syndrome.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Mar 2016

Goodliffe Joseph W, Olmos-Serrano Jose Luis, Aziz Nadine M, Pennings Jeroen L A, Guedj Faycal, Bianchi Diana W, Haydar Tarik F

Abstract excerpt

Studies in humans with Down syndrome (DS) show that alterations in fetal brain development are followed by postnatal deficits in neuronal numbers, synaptic plasticity, and cognitive and motor function. This same progression is replicated in several mouse models of DS. Dp(16)1Yey/+ (hereafter called Dp16) is a recently developed mouse model of DS in which the entire region of mouse chromosome 16 that is homologous...

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Identifiers

PMID: 26961948
DOI: 10.1523/JNEUROSCI.2513-15.2016
PMCID: PMC4783496

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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