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Article

Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.

Diabetologia - 1 Jun 2016

Wood Andrew R, Tyrrell Jessica, Beaumont Robin, Jones Samuel E, Tuke Marcus A, Ruth Katherine S, Yaghootkar Hanieh, Freathy Rachel M, Murray Anna, Frayling Timothy M, Weedon Michael N

Abstract excerpt

AIMS/HYPOTHESIS: Genome-wide association (GWA) studies have identified hundreds of common genetic variants associated with obesity and type 2 diabetes. These studies have usually focused on additive association tests. Identifying deviations from additivity may provide new biological insights and explain some of the missing heritability for these diseases. METHODS: We performed a GWA study using a dominance...

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Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Share to Body Mass Index

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

Share to Genome-Wide Association Study

Share to Models, Statistical

Share to Obesity

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Source

Open in PubMed Open full text

Identifiers

PMID: 26961502
DOI: 10.1007/s00125-016-3908-5
PMCID: PMC4869698

Genes

CDKAL1
FTO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.PMID 26961502Read ↗

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