Article
Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians.
Diabetologia - 1 Apr 2012
Li H, Kilpeläinen T O, Liu C, Zhu J, Liu Y, Hu C, Yang Z, Zhang W, Bao W, Cha S, Wu Y, Yang T, Sekine A, Choi B Y, Yajnik C S, Zhou D, Takeuchi F, Yamamoto K, Chan J C, Mani K R, Been L F, Imamura M, Nakashima E, Lee N, Fujisawa T, Karasawa S, Wen W, Joglekar C V, Lu W, Chang Y, Xiang Y, Gao Y, Liu S, Song Y, Kwak S H, Shin H D, Park K S, Fall C H D, Kim J Y, Sham P C, Lam K S L, Zheng W, Shu X, Deng H, Ikegami H, Krishnaveni G V, Sanghera D K, Chuang L, Liu L, Hu R, Kim Y, Daimon M, Hotta K, Jia W, Kooner J S, Chambers J C, Chandak G R, Ma R C, Maeda S, Dorajoo R, Yokota M, Takayanagi R, Kato N, Lin X, Loos R J F
Abstract excerpt
AIMS/HYPOTHESIS: FTO harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To test whether there is an association of the FTO locus with obesity and type 2 diabetes, we conducted a meta-analysis of 32 populations including 96,551 East and...
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