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Article

Endonuclease domain of non-LTR retrotransposons: loss-of-function mutants and modeling of the R2Bm endonuclease.

Nucleic acids research - 20 Apr 2016

Govindaraju Aruna, Cortez Jeremy D, Reveal Brad, Christensen Shawn M

Abstract excerpt

Non-LTR retrotransposons are an important class of mobile elements that insert into host DNA by target-primed reverse transcription (TPRT). Non-LTR retrotransposons must bind to their mRNA, recognize and cleave their target DNA, and perform TPRT at the site of DNA cleavage. As DNA binding and cleavage are such central parts of the integration reaction, a better understanding of the endonuclease encoded by non-LTR...

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Identifiers

PMID: 26961309
DOI: 10.1093/nar/gkw134
PMCID: PMC4838377

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Source receipt: pubmed, retrieved 7 Sept 2026.

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