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Article

Inheritance of the Bantu/Benin haplotype causes less severe hemolytic and oxidative stress in sickle cell anemia patients treated with hydroxycarbamide.

Journal of human genetics - 1 Jul 2016

Okumura Jéssika V, Silva Danilo G H, Torres Lidiane S, Belini-Junior Edis, Barberino Willian M, Oliveira Renan G, Carrocini Gisele C S, Gelaleti Gabriela B, Lobo Clarisse L C, Bonini-Domingos Claudia R

Abstract excerpt

Beta S-globin gene cluster haplotypes (β(S)-haplotypes) can modulate the response to hydroxycarbamide (HC) treatment in sickle cell anemia (SCA) patients. In Brazil, the most common haplotypes are Bantu and Benin, and both confer a poor prognosis for patients when untreated with HC. We evaluated oxidative and hemolytic biomarkers in 48 SCA patients undergoing HC treatment separated in three subgroups:...

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Share to Anemia, Sickle Cell
Share to Hemoglobin, Sickle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26961071
DOI: 10.1038/jhg.2016.16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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