Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic and biochemical markers of hydroxyurea therapeutic response in sickle cell anemia.

BMC medical genetics - 9 Oct 2013

Silva Danilo Grunig Humberto, Belini Junior Edis, Carrocini Gisele Cristine de Souza, Torres Lidiane de Souza, Ricci Júnior Octávio, Lobo Clarisse Lopes de Castro, Bonini-Domingos Claudia Regina, de Almeida Eduardo Alves

Abstract excerpt

BACKGROUND: Sickle cell anemia (SCA) presents a complex pathophysiology which can be affected by a number of modifying factors, including genetic and biochemical ones. In Brazil, there have been no studies verifying βS-haplotypes effect on oxidative stress parameters. This study evaluated βS-haplotypes and Hb F levels effects on oxidative stress markers and their relationship with hydroxyurea (HU) treatment in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anemia, Sickle Cell
Share to Fetal Hemoglobin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutathione

Share to Hemoglobin, Sickle

Share to Hydroxyurea

Share to Lipid Peroxidation

Share to Oxidative Stress

Share to Spectrophotometry

Source

Open in PubMed Open full text

Identifiers

PMID: 24106994
DOI: 10.1186/1471-2350-14-108
PMCID: PMC3851873

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic and biochemical markers of hydroxyurea therapeutic response in sickle cell anemia.PMID 24106994Read ↗

Influence of βS allele in the lipid peroxidation and antioxidant capacity parameters.Semantic proximity Read ↗

Biological impact of α genes, β haplotypes, and G6PD activity in sickle cell anemia at baseline and with hydroxyurea.Semantic proximity Read ↗

Inheritance of the Bantu/Benin haplotype causes less severe hemolytic and oxidative stress in sickle cell anemia patients treated with hydroxycarbamide.Semantic proximity Read ↗

Relationship between oxidative stress, glutathione S-transferase polymorphisms and hydroxyurea treatment in sickle cell anemia.Semantic proximity Read ↗

Pharmacogenomics and therapeutics of hemoglobinopathies.Semantic proximity Read ↗

Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters.Semantic proximity Read ↗

BCL11A and HBS1L-MYB polymorphisms, in association with hydroxyurea and sex, modulate fetal hemoglobin levels in individuals with sickle cell anemia in the western region of Bahia, Brazil.Semantic proximity Read ↗

The influence of hydroxyurea on oxidative stress in sickle cell anemiaSemantic proximity Read ↗

Exploring Pharmacogenetic Factors Influencing Hydroxyurea Response in Tanzanian Sickle Cell Disease Patients: A Genomic Medicine ApproachSemantic proximity Read ↗

Gene polymorphisms predicting response to hydroxyurea treatment in Bahraini patients with sickle cell disease.Semantic proximity Read ↗

Exploring pharmacogenetic factors influencing hydroxyurea response in tanzanian sickle cell disease patients: a genomic medicine approach.Semantic proximity Read ↗

[Population characterization of mutations for sickle cell anemia and its treatment: One step towards personalized medicine for the disease].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.