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Article

The association of single nucleotide polymorphisms of the maternal cystathionine-β-synthase gene with early-onset preeclampsia.

Pregnancy hypertension - 1 Jan 2016

Holwerda Kim M, Weedon-Fekjær M Susanne, Staff Anne C, Nolte Ilja M, van Goor Harry, Lely A Titia, Faas Marijke M

Abstract excerpt

OBJECTIVES: Preeclampsia (PE) is a pregnancy complication, characterized by hypertension and proteinuria. The transsulfuration pathway may be involved in its pathophysiology, since homocysteine, cystathionine and cysteine are increased in PE. Cystathionine-β-synthase (CBS) is a key-enzyme in the pathway, converting homocysteine into cysteine via cystathionine. Another product of CBS is hydrogen sulfide (H2S), a...

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PMID: 26955774
DOI: 10.1016/j.preghy.2015.12.001

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CBS

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