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Article

Polymorphisms in methionine synthase reductase and betaine-homocysteine S-methyltransferase genes: risk of placental abruption.

Molecular genetics and metabolism - 1 May 2007

Ananth Cande V, Elsasser Denise A, Kinzler Wendy L, Peltier Morgan R, Getahun Darios, Leclerc Daniel, Rozen Rima R

Abstract excerpt

OBJECTIVES: Methionine synthase reductase (MTRR) and betaine-homocysteine S-methyltransferase (BHMT) are two enzymes that regulate homocysteine metabolism. Elevated homocysteine (hyperhomocysteinemia) is associated with adverse pregnancy outcomes and vascular disease. We assessed whether polymorphisms in MTRR (66A-->G; I22M) and BHMT (742G-->A; R239Q) were associated with abruption. We further evaluated whether...

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Source

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Identifiers

PMID: 17376725
DOI: 10.1016/j.ymgme.2007.02.004
PMCID: PMC1885454

Genes

BHMT
MTRR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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