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Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction.

DNA repair - 21 Nov 2005

Wijnhoven Susan W P, Beems Rudolf B, Roodbergen Marianne, van den Berg Jolanda, Lohman Paul H M, Diderich Karin, van der Horst Gijsbertus T J, Vijg Jan, Hoeijmakers Jan H J, van Steeg Harry

Abstract excerpt

Trichothiodystrophy (TTD) patients with a mutation in the XPD gene of nucleotide excision repair (NER) have a short life span and show various features of premature aging, thereby linking DNA damage to the aging process. Xpd(TTD) mutant mice share many features with TTD patients, including a shorter life span, accompanied by a segmental progeroid phenotype. Here we report new pathology features supportive to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16115803
DOI: 10.1016/j.dnarep.2005.07.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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