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Article

The Hypoglycemic Phenotype Is Islet Cell-Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase-Deficient Mice.

Diabetes - 1 Jun 2016

Molven Anders, Hollister-Lock Jennifer, Hu Jiang, Martinez Rachael, Njølstad Pål R, Liew Chong Wee, Weir Gordon, Kulkarni Rohit N

Abstract excerpt

Congenital hyperinsulinism of infancy (CHI) can be caused by inactivating mutations in the gene encoding short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD), a ubiquitously expressed enzyme involved in fatty acid oxidation. The hypersecretion of insulin may be explained by a loss of interaction between SCHAD and glutamate dehydrogenase in the pancreatic β-cells. However, there is also a general accumulation of...

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Identifiers

PMID: 26953163
DOI: 10.2337/db15-1475
PMCID: PMC4878426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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