Article
In vitro insulin secretion by pancreatic tissue from infants with diazoxide-resistant congenital hyperinsulinism deviates from model predictions.
The Journal of clinical investigation - 1 Oct 2011
Henquin Jean-Claude, Nenquin Myriam, Sempoux Christine, Guiot Yves, Bellanné-Chantelot Christine, Otonkoski Timo, de Lonlay Pascale, Nihoul-Fékété Claire, Rahier Jacques
Abstract excerpt
Congenital hyperinsulinism (CHI) is the major cause of persistent neonatal hypoglycemia. CHI most often occurs due to mutations in the ABCC8 (which encodes sulfonylurea receptor 1) or KCNJ11 (which encodes the potassium channel Kir6.2) gene, which result in a lack of functional KATP channels in pancreatic β cells. Diffuse forms of CHI (DiCHI), in which all β cells are abnormal, often require subtotal...
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