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Recruitment of mismatch repair proteins to the site of DNA damage in human cells

3 Sept 2008

Abstract excerpt

Mismatch repair (MMR) proteins contribute to genome stability by excising DNA mismatches introduced by DNA polymerase. Although MMR proteins are also known to influence cellular responses to DNA damage, how MMR proteins respond to DNA damage within the cell remains unknown. Here, we show that MMR proteins are recruited immediately to the sites of various types of DNA damage in human cells. MMR proteins are...

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PMID: 18765568
DOI: 10.1242/jcs.026393

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