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Article

Focal expression of mutant huntingtin in the songbird basal ganglia disrupts cortico-basal ganglia networks and vocal sequences.

Proceedings of the National Academy of Sciences of the United States of America - 22 Mar 2016

Tanaka Masashi, Singh Alvarado Jonnathan, Murugan Malavika, Mooney Richard

Abstract excerpt

The basal ganglia (BG) promote complex sequential movements by helping to select elementary motor gestures appropriate to a given behavioral context. Indeed, Huntington's disease (HD), which causes striatal atrophy in the BG, is characterized by hyperkinesia and chorea. How striatal cell loss alters activity in the BG and downstream motor cortical regions to cause these disorganized movements remains unknown....

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Identifiers

PMID: 26951661
DOI: 10.1073/pnas.1523754113
PMCID: PMC4812762

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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