Article
Pharmacokinetics of Rasagiline in Healthy Adult Chinese Volunteers with Various Genotypes: A Single-Center, Open-Label, Multiple-Dose Study.
Clinical drug investigation - 1 May 2016
Chen Xia, Zhao Qian, Jiang Ji, Liu Jian, Hu Pei
Abstract excerpt
BACKGROUND AND OBJECTIVE: Although there is evidence indicating cytochome P450 (CYP) 1A2 is responsible for the metabolism of rasagiline, the role of other CYP isoforms is unclear. This study investigated the pharmacokinetics of rasagiline in adult Chinese healthy volunteers with various CYP genotypes. METHODS: This single-center, open-label study was conducted in 12 subjects. Fasted subjects received rasagiline...
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