Article
In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren.
Pharmacology research & perspectives - 1 Apr 2020
Kong Ronald, Ma Jiyuan, Hwang Seongwoo, Moon Young-Choon, Welch Ellen M, Weetall Marla, Colacino Joseph M, Almstead Neil, Babiak John, Goodwin Elizabeth
Abstract excerpt
Ataluren promotes ribosomal readthrough of premature termination codons in mRNA which result from nonsense mutations. In vitro studies were performed to characterize the metabolism and enzyme kinetics of ataluren and its interaction potential with CYP enzymes. Incubation of [14 C]-ataluren with human liver microsomes indicated that the major metabolic pathway for ataluren is via direct glucuronidation and that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.