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Article

Investigation on modulation of human P-gp by multiple doses of Radix Astragali extract granules using fexofenadine as a phenotyping probe.

Journal of ethnopharmacology - 19 Apr 2013

Zhou Quan, Ye Zhen, Ruan Zourong, Zeng Su

Abstract excerpt

ETHNOPHARMACOLOGY: Herb-drug interactions may potentially affect drug efficacy and/or the likelihood of adverse drug reactions. Radix Astragali (RA) extract formulation is usually prescribed for long-term use for patients with immunodeficiency, diabetes, nephropathy or cardiovascular diseases. Its use in combination with P-glycoprotein (P-gp) substrates is possible in clinical practice. Currently there is little...

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatography, High Pressure Liquid

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Share to Dose-Response Relationship, Drug

Share to Drugs, Chinese Herbal

Share to Polymorphism, Single Nucleotide

Share to Substrate Specificity

Source

Identifiers

PMID: 23422332
DOI: 10.1016/j.jep.2013.01.037

Genes

ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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