Article
Nuclear Drosophila CerS Schlank regulates lipid homeostasis via the homeodomain, independent of the lag1p motif.
FEBS letters - 1 Apr 2016
Voelzmann André, Wulf Anna-Lena, Eckardt Franka, Thielisch Melanie, Brondolin Mirco, Pesch Yanina-Yasmin, Sociale Mariangela, Bauer Reinhard, Hoch Michael
Abstract excerpt
Drosophila Ceramide Synthase (CerS) Schlank regulates both ceramide synthesis and fat metabolism. Schlank contains a catalytic lag1p motif and, like many CerS in other species, a homeodomain of unknown function. Here, we show that the Drosophila CerS Schlank is imported into the nucleus and requires two nuclear localization signals (NLSs) within its homeodomain and functional Importin-β import machinery....
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