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Comprehensive clinicopathological and genomic profiling of gallbladder cancer reveals actionable targets in half of patients

5 Nov 2022

Abstract excerpt

Gallbladder cancer (GBC) is a rare, highly aggressive malignancy with a 5-year survival rate of 5-10% in advanced cases, highlighting the need for more effective therapies. The aim of this study was to identify potentially actionable therapeutic targets for GBC. Specimens and clinicopathological data of 642 GBC patients, diagnosed between 2000 and 2019 were collected using the Dutch Pathology Registry (PALGA) and...

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PMID: 36335173
DOI: 10.1038/s41698-022-00327-y

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