Article
Update of genetics in colorectal carcinomas: genomic instability and somatic evolution.
Annals of the Academy of Medicine, Singapore - 1 May 2000
Cheah P Y, Eu K W, Seow F C
Abstract excerpt
INTRODUCTION: Currently, there are two contrasting viewpoints on what drives the process of carcinogenesis. The genomic (DNA or chromosomal) instability model contends that an increased mutation rate early in carcinogenesis is necessary for the multistage process, while the somatic evolution model postulates that normal mutation rate with selective advantage and clonal expansion is sufficient to cause cancer....
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