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Article

Roles of distinct cysteine residues in S-nitrosylation and dimerization of DJ-1.

Biochemical and biophysical research communications - 13 Jan 2006

Ito Genta, Ariga Hiroyoshi, Nakagawa Yasuhito, Iwatsubo Takeshi

Abstract excerpt

A significant proportion of early onset parkinsonism is inherited as an autosomal-recessive trait (AR-EP). DJ-1 was identified as one of the causative genes for AR-EP (PARK7), and DJ-1 protein has been implicated in oxidative stress response through oxidation of one of the three cysteine residues (i.e., Cys106). However, the individual roles of these cysteine residues remained unclear. We show by a systematic...

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Source

Identifiers

PMID: 16316629
DOI: 10.1016/j.bbrc.2005.11.058

Genes

PARK7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Roles of distinct cysteine residues in S-nitrosylation and dimerization of DJ-1.PMID 16316629Read ↗

Structural features of human DJ-1 in distinct Cys106 oxidative states and their relevance to its loss of function in disease.Semantic proximity Read ↗

Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1.Semantic proximity Read ↗

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Effect of single amino acid substitution on oxidative modifications of the Parkinson's disease-related protein, DJ-1.Semantic proximity Read ↗

A novel splicing variant of DJ-1 in Parkinson's disease induces mitochondrial dysfunctionSemantic proximity Read ↗

Monomer DJ-1 and its N-terminal sequence are necessary for mitochondrial localization of DJ-1 mutants.Semantic proximity Read ↗

DJ-1 is indispensable for the S-nitrosylation of Parkin, which maintains function of mitochondriaSemantic proximity Read ↗

C Terminus of DJ-1 Determines Its Homodimerization, Deglycation Activity and Suppression of FerroptosisSemantic proximity Read ↗

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