Article
Modifying the resolving cysteine affects the structure and hydrogen peroxide reactivity of peroxiredoxin 2.
The Journal of biological chemistry - 1 Jan 2000
Peskin Alexander V, Meotti Flavia C, Kean Kelsey M, Göbl Christoph, Peixoto Albert Souza, Pace Paul E, Horne Christopher R, Heath Sarah G, Crowther Jennifer M, Dobson Renwick C J, Karplus P Andrew, Winterbourn Christine C
Abstract excerpt
Peroxiredoxin 2 (Prdx2) is a thiol peroxidase with an active site Cys (C52) that reacts rapidly with H2O2 and other peroxides. The sulfenic acid product condenses with the resolving Cys (C172) to form a disulfide which is recycled by thioredoxin or GSH via mixed disulfide intermediates or undergoes hyperoxidation to the sulfinic acid. C172 lies near the C terminus, outside the active site. It is not established...
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