Article
Activation of proto-oncogenes by disruption of chromosome neighborhoods.
Science (New York, N.Y.) - 25 Mar 2016
Hnisz Denes, Weintraub Abraham S, Day Daniel S, Valton Anne-Laure, Bak Rasmus O, Li Charles H, Goldmann Johanna, Lajoie Bryan R, Fan Zi Peng, Sigova Alla A, Reddy Jessica, Borges-Rivera Diego, Lee Tong Ihn, Jaenisch Rudolf, Porteus Matthew H, Dekker Job, Young Richard A
Abstract excerpt
Oncogenes are activated through well-known chromosomal alterations such as gene fusion, translocation, and focal amplification. In light of recent evidence that the control of key genes depends on chromosome structures called insulated neighborhoods, we investigated whether proto-oncogenes occur within these structures and whether oncogene activation can occur via disruption of insulated neighborhood boundaries...
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