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Article

Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo

4 Mar 2016

Abstract excerpt

Dysfunction and accumulation of the microtubule-associated human Tau (hTau) protein into intraneuronal aggregates is observed in many neurodegenerative disorders including Alzheimer's disease (AD). Reversible lysine acetylation has recently emerged as a post-translational modification that may play an important role in the modulation of hTau pathology. Acetylated hTau species have been observed within hTau...

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PMID: 26940749
DOI: 10.1038/srep22685

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