Article
MICA*A4 protects against ulcerative colitis, whereas MICA*A5.1 is associated with abscess formation and age of onset.
Clinical and experimental immunology - 1 Jun 2016
Martinez-Chamorro A, Moreno A, Gómez-García M, Cabello M J, Martin J, Lopez-Nevot M Á
Abstract excerpt
Ulcerative colitis (UC) is one of the two major forms of inflammatory bowel disease, the aetiology of which remains unknown. Several studies have demonstrated the genetic basis of disease, identifying more than 130 susceptibility loci. The major histocompatibility complex class I chain-related gene A (MICA) is a useful candidate to be involved in UC pathogenesis, because it could be important in recognizing the...
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