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Article

MiR-185 attenuates androgen receptor function in prostate cancer indirectly by targeting bromodomain containing 8 isoform 2, an androgen receptor co-activator.

Molecular and cellular endocrinology - 15 May 2016

Jiang Chen-Yi, Ruan Yuan, Wang Xiao-Hai, Zhao Wei, Jiang Qi, Jing Yi-Feng, Han Bang-Min, Xia Shu-Jie, Zhao Fu-Jun

Abstract excerpt

OBJECTIVES: Aberrant androgen receptor (AR) signaling functions are implicated in prostate cancer (PCa) pathogenesis. Here, we studied interactions between miR-185 and the bromodomain containing 8 isoform 2 (BRD8 ISO2) to investigate indirect mechanisms of miR-185 with respect to AR function through BRD8 ISO2 in PCa. METHODS: Putative miRNA response element (MRE) of miR-185 in 3'-untranslated region (3'-UTR) of...

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Identifiers

PMID: 26940039
DOI: 10.1016/j.mce.2016.02.023

Genes

BRD8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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