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Article

CRISPR-Cas9-mediated loss of function of β-catenin attenuates intervertebral disc degeneration

28 Mar 2022

Abstract excerpt

Intervertebral disc degeneration is a very common medical condition causing pain and disability, and it cannot be reversed by available treatment options. Here we report that targeting β-catenin, a pivotal factor associated with disc degeneration, ameliorates disc degeneration in a mouse model of disc injury. Degenerative changes in the disc in response to disc injury include decompression of nucleus pulposus...

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PMID: 35505959
DOI: 10.1016/j.omtn.2022.03.024

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