Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration

5 Aug 2008

Abstract excerpt

INTRODUCTION: Chronic and debilitating low back pain is a common condition and a huge economic burden. Many cases are attributed to age-related degeneration of the intervertebral disc (IVD); however, age-related degeneration appears to occur at an accelerated rate in some individuals. We have previously demonstrated biomarkers of cellular senescence within the human IVD and suggested a role for senescence in IVD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caveolin-1 and cellular processes
Share to Spine and Intervertebral Disc Pathology
Share to Spondyloarthritis Studies and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18681962
DOI: 10.1186/ar2468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degenerationPMID 18681962Read ↗

Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degenerationSemantic proximity Read ↗

Aging, cell senescence, the pathogenesis and targeted therapies of intervertebral disc degenerationSemantic proximity Read ↗

Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degenerationSemantic proximity Read ↗

Toll-Like Receptor 2 Induced Senescence in Intervertebral Disc Cells of Patients with Back Pain can be Attenuated by o-VanilinSemantic proximity Read ↗

TMT-Based Proteomics Analysis of Senescent Nucleus Pulposus from Patients with Intervertebral Disc DegenerationSemantic proximity Read ↗

Mechanisms and therapeutic strategies for senescence-associated secretory phenotype in the intervertebral disc degeneration microenvironmentSemantic proximity Read ↗

BRD4 / MAP2K7 / PGF Signaling Axis Promotes Senescence and Extracellular Matrix Metabolism of Nucleus Pulposus Cells in Intervertebral Disk DegenerationSemantic proximity Read ↗

Senescence mechanisms of nucleus pulposus chondrocytes in human intervertebral discsSemantic proximity Read ↗

Unraveling the mechanisms of intervertebral disc degeneration: an exploration of the p38 MAPK signaling pathwaySemantic proximity Read ↗

[Research progress of cellular senescence and senescent secretary phenotype in intervertebral disc degeneration].Semantic proximity Read ↗

FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degenerationSemantic proximity Read ↗

Identification and validation of cellular senescence-related genes and immune cell infiltration characteristics in intervertebral disc degenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.