Article
Leishmania amazonensis arginase compartmentalization in the glycosome is important for parasite infectivity.
PloS one - 1 Jan 2012
da Silva Maria Fernanda Laranjeira, Zampieri Ricardo Andrade, Muxel Sandra M, Beverley Stephen M, Floeter-Winter Lucile M
Abstract excerpt
In Leishmania, de novo polyamine synthesis is initiated by the cleavage of L-arginine to urea and L-ornithine by the action of arginase (ARG, E.C. 3.5.3.1). Previous studies in L. major and L. mexicana showed that ARG is essential for in vitro growth in the absence of polyamines and needed for full infectivity in animal infections. The ARG protein is normally found within the parasite glycosome, and here we...
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