Article
Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway.
Inflammatory bowel diseases - 1 Apr 2016
Kaur Manreet, Panikkath Deepa, Yan Xiaofei, Liu Zhenqiu, Berel Dror, Li Dalin, Vasiliauskas Eric A, Ippoliti Andrew, Dubinsky Marla, Shih David Q, Melmed Gil Y, Haritunians Talin, Fleshner Phillip, Targan Stephan R, McGovern Dermot P B
Abstract excerpt
BACKGROUND: Perianal Crohn's Disease (pCD) is a particularly severe phenotype associated with poor quality of life with a reported prevalence of 12%-40%. Previous studies investigating the etiology of pCD have been limited in the numbers of subjects and the intensity of genotyping. The aim of this study was to identify clinical, serological, and genetic factors associated with pCD. METHODS: We performed a...
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