Article
Novel Role for Protein Inhibitor of Activated STAT 4 (PIAS4) in the Restriction of Herpes Simplex Virus 1 by the Cellular Intrinsic Antiviral Immune Response.
Journal of virology - 1 May 2016
Conn Kristen L, Wasson Peter, McFarlane Steven, Tong Lily, Brown James R, Grant Kyle G, Domingues Patricia, Boutell Chris
Abstract excerpt
UNLABELLED: Small ubiquitin-like modifier (SUMO) is used by the intrinsic antiviral immune response to restrict viral pathogens, such as herpes simplex virus 1 (HSV-1). Despite characterization of the host factors that rely on SUMOylation to exert their antiviral effects, the enzymes that mediate these SUMOylation events remain to be defined. We show that unconjugated SUMO levels are largely maintained throughout...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.