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Article

Kaposi's sarcoma-associated herpesvirus K-Rta exhibits SUMO-targeting ubiquitin ligase (STUbL) like activity and is essential for viral reactivation.

PLoS pathogens - 1 Jan 2013

Izumiya Yoshihiro, Kobayashi Keisuke, Kim Kevin Y, Pochampalli Mamata, Izumiya Chie, Shevchenko Bogdan, Wang Don-Hong, Huerta Steve B, Martinez Anthony, Campbell Mel, Kung Hsing-Jien

Abstract excerpt

The small ubiquitin-like modifier (SUMO) is a protein that regulates a wide variety of cellular processes by covalent attachment of SUMO moieties to a diverse array of target proteins. Sumoylation also plays an important role in the replication of many viruses. Previously, we showed that Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a SUMO-ligase, K-bZIP, which catalyzes sumoylation of host and viral...

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Share to Basic-Leucine Zipper Transcription Factors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Herpesvirus 8, Human

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Identifiers

PMID: 23990779
DOI: 10.1371/journal.ppat.1003506
PMCID: PMC3749962

Genes

PML
RNF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Kaposi's sarcoma-associated herpesvirus K-Rta exhibits SUMO-targeting ubiquitin ligase (STUbL) like activity and is essential for viral reactivation.PMID 23990779Read ↗

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