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Article

The RNA Helicase eIF4A Is Required for Sapovirus Translation.

Journal of virology - 15 May 2016

Hosmillo Myra, Sweeney Trevor R, Chaudhry Yasmin, Leen Eoin, Curry Stephen, Goodfellow Ian, Cho Kyoung-Oh

Abstract excerpt

The eukaryotic initiation factor 4A (eIF4A) is a DEAD box helicase that unwinds RNA structure in the 5' untranslated region (UTR) of mRNAs. Here, we investigated the role of eIF4A in porcine sapovirus VPg-dependent translation. Using inhibitors and dominant-negative mutants, we found that eIF4A is required for viral translation and infectivity, suggesting that despite the presence of a very short 5' UTR, eIF4A is...

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Share to 5' Untranslated Regions
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26937032
DOI: 10.1128/JVI.03174-15
PMCID: PMC4859703

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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