Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition

13 Jul 2020

Abstract excerpt

RNA-activated protein kinase (PKR) is one of the most powerful antiviral defense factors of the mammalian host. PKR acts by phosphorylating mRNA translation initiation factor eIF2α, thereby converting it from a cofactor to an inhibitor of mRNA translation that strongly binds to initiation factor eIF2B. To sustain synthesis of their proteins, viruses are known to counteract this on the level of PKR or eIF2α or by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA regulation and disease
Share to Viral gastroenteritis research and epidemiology
Share to Viral Infections and Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32665273
DOI: 10.1128/mbio.00976-20

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

eIF2B as a Target for Viral Evasion of PKR-Mediated Translation InhibitionPMID 32665273Read ↗

NSs Protein of Sandfly Fever Sicilian Phlebovirus Counteracts Interferon (IFN) Induction by Masking the DNA-Binding Domain of IFN Regulatory Factor 3Semantic proximity Read ↗

Dual Functions of Rift Valley Fever Virus NSs Protein: Inhibition of Host mRNA Transcription and Post‐transcriptional Downregulation of Protein Kinase PKRSemantic proximity Read ↗

Phleboviruses and the Type I Interferon ResponseSemantic proximity Read ↗

Rift Valley Fever Virus NSs Protein Promotes Post-Transcriptional Downregulation of Protein Kinase PKR and Inhibits eIF2α PhosphorylationSemantic proximity Read ↗

Characterisation of the Semliki Forest Virus-host cell interactome reveals the viral capsid protein as an inhibitor of nonsense-mediated mRNA decaySemantic proximity Read ↗

Poliovirus Switches to an eIF2-Independent Mode of Translation during InfectionSemantic proximity Read ↗

NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase.Semantic proximity Read ↗

African swine fever virus MGF505-7R protein interacted with IRF7and TBK1 to inhibit type I interferon productionSemantic proximity Read ↗

Zika virus non-coding RNAs antagonize antiviral responses by PKR-mediated translational arrestSemantic proximity Read ↗

Adaptive Changes in Alphavirus mRNA Translation Allowed Colonization of Vertebrate HostsSemantic proximity Read ↗

Novel Function of African Swine Fever Virus pE66L in Inhibition of Host Translation by the PKR/eIF2α PathwaySemantic proximity Read ↗

Flavivirus Infection Uncouples Translation Suppression from Cellular Stress ResponsesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.