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Article

Exome sequencing of oral squamous cell carcinoma in users of Arabian snuff reveals novel candidates for driver genes.

International journal of cancer - 15 Jul 2016

Al-Hebshi Nezar Noor, Li Shiyong, Nasher Akram Thabet, El-Setouhy Maged, Alsanosi Rashad, Blancato Jan, Loffredo Christopher

Abstract excerpt

The study sought to identify genetic aberrations driving oral squamous cell carcinoma (OSCC) development among users of shammah, an Arabian preparation of smokeless tobacco. Twenty archival OSCC samples, 15 of which with a history of shammah exposure, were whole-exome sequenced at an average depth of 127×. Somatic mutations were identified using a novel, matched controls-independent filtration algorithm. CODEX...

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Topics

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mouth Neoplasms

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Source

Open in PubMed Open full text

Identifiers

PMID: 26934577
DOI: 10.1002/ijc.30068
PMCID: PMC5821466

Genes

BAG1
CASP8
CCND1
CLTCL1
CRB1
CSMD3
FADD
FAT1
FOSL1
FRS2
HRAS
MDM2
MYB
NOTCH3
OSMR
RELA
SMARCC1
TRAF6
TRPM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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