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Article

Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1.

Protein science : a publication of the Protein Society - 1 May 2010

Zhang Mengmeng, Liu June, Kim Youngjun, Dixon Jack E, Pfaff Samuel L, Gill Gordon N, Noel Joseph P, Zhang Yan

Abstract excerpt

Human small C-terminal domain phosphatase 1 (Scp1) modulates the phosphorylation state of the C-terminal domain (CTD) of eukaryotic RNA polymerase II (RNAP II), with preference for phosphorylated Ser5 in the tandem heptad repeats of the CTD. Additionally, Scp1 was identified as a conserved regulator of neuronal stem cell development. Scp1 is a member of haloacid dehalogenase (HAD) superfamily, whose catalysis...

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PMID: 20222012
DOI: 10.1002/pro.375
PMCID: PMC2868240

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