Article
A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.
The Journal of antimicrobial chemotherapy - 1 Aug 2010
Song Yajun, Roumagnac Philippe, Weill François-Xavier, Wain John, Dolecek Christiane, Mazzoni Camila J, Holt Kathryn E, Achtman Mark
Abstract excerpt
OBJECTIVES: Decreased susceptibility to fluoroquinolones has become a major problem for the successful therapy of human infections caused by Salmonella enterica, especially the life-threatening typhoid and paratyphoid fevers. METHODS: By using Luminex xTAG beads, we developed a rapid, reliable and cost-effective multiplexed genotyping assay for simultaneously detecting 11 mutations in gyrA, gyrB and parE of S....
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