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Article

Gliosarcomas lack BRAFV600E mutation, but a subset exhibit β-catenin nuclear localization.

Neuropathology : official journal of the Japanese Society of Neuropathology - 1 Oct 2016

Schwetye Katherine E, Joseph Nancy M, Al-Kateb Hussam, Rich Keith M, Schmidt Robert E, Perry Arie, Gutmann David H, Dahiya Sonika

Abstract excerpt

Gliosarcoma (GS) is a rare subtype of glioblastoma (GBM) characterized by both glial and mesenchymal components. Unlike GBM, there are no specific prognostic markers, and optimized treatments for patients with GS do not exist. Recent reports describe BRAFV600E mutation in malignant peripheral nerve sheath tumors, and aberrant Wnt signaling and CTNNB1 (β-catenin gene) mutations have been described in GBM. We...

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PMID: 26932501
DOI: 10.1111/neup.12293

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CTNNB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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