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Article

BRAF V600E mutation is associated with mTOR signaling activation in glioneuronal tumors.

Brain pathology (Zurich, Switzerland) - 1 Jan 2014

Prabowo Avanita S, Iyer Anand M, Veersema Tim J, Anink Jasper J, Schouten-van Meeteren Antoinette Y N, Spliet Wim G M, van Rijen Pieter C, Ferrier Cyrille H, Capper David, Thom Maria, Aronica Eleonora

Abstract excerpt

BRAF V600E mutations have been recently reported in glioneuronal tumors (GNTs). To evaluate the expression of the BRAF V600E mutated protein and its association with activation of the mammalian target of rapamycin (mTOR) pathway, immunophenotype and clinical characteristics in GNTs, we investigated a cohort of 174 GNTs. The presence of BRAF V600E mutations was detected by direct DNA sequencing and BRAF V600E...

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Identifiers

PMID: 23941441
DOI: 10.1111/bpa.12081
PMCID: PMC8029322

Genes

BRAF

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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