Article
BRAF gene alterations and enhanced mammalian target of rapamycin signaling in gangliogliomas.
Neurology India - 1 Jan 2000
Kakkar Aanchal, Majumdar Atreye, Pathak Pankaj, Kumar Anupam, Kumari Kalpana, Tripathi Manjari, Sharma Mehar C, Suri Vaishali, Tandon Vivek, Chandra Sarat P, Sarkar Chitra
Abstract excerpt
BACKGROUND: Gangliogliomas (GGs) are slow-growing glioneuronal tumors seen in children and young adults. They are associated with intractable epilepsy, and have recently been found to harbor BRAF (B- rapidly accelerated fibrosarcoma) gene mutations. However, the mammalian target of rapamycin (mTOR) signaling pathway, downstream of BRAF, has not been evaluated extensively in GGs. MATERIALS AND METHODS: GG cases...
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